Stem cells work stimulating cell growth activating collagen while protecting skin against any future damage and moisture loss. They were divided into a control group C, an experimental group E1 using ADSC-CM 5%, and an experimental group E2 using polymersome-containing of ADSC-CM 5%, and there were 20 subjects in each group. - eBay Money Back Guarantee - opens in a new window or tab, - for PayPal Credit, opens in a new window or tab, Learn more about earning points with eBay Mastercard, - eBay Return policy - opens in a new tab or window, - eBay Money Back Guarantee - opens in a new tab or window. There you have it: the real-deal behind stem cell use in skin care! Go ahead: try this groundbreaking product and watch your skin hydrate and regenerate before your eyes. Choosing a selection results in a full page refresh. Yang EJ. Spend $35 more and get free shipping in the contiguous US! We always formulate without 1,300+ Banned Ingredients, Including: Parabens, Mineral Oil, Sulfate-based Detergents, Synthetic Fragrance, Petroleum-based Ingredients, Phthalates, Phenoxyethanol, Formaldehyde and GMO Ingredients. Group C showed a significant increase of roughness in the right cheekbone of 0.54(M), from 5.55(M) to 6.09(M) (p<.001), group E1 showed a significant decrease of 0.30(M), from 6.30(M) to 6.00(M) (p<.05), and group E2 showed a statistically significant decrease of 0.47(M), from 5.59(M) to 5.12(M) (p<.001). A Master's thesis of Kangwon National University. The changes in eye wrinkle depth for groups C, E1, and E2 are presented in Table10. Are you ready to give it a go? Repair effect of human adipose tissue derived stem cell on photoaged skin in albino hairless mouse. Kim YE. The increase in moisture content and the decrease in TEWL in the experimental groups in comparison to the control group in the present study, as shown in Tables5 and 6, are consistent with those in the previous studies cited. Academically, studies on the cytotherapy effect and skin regeneration using human stem cell-derived releasing factors have been performed. 
This formulation is a genuine scientific breakthrough that required decades of research and hard work to bring to market. 2011;63:124756 https://www.ncbi.nlm.nih.gov/pubmed/21605607 Accessed 2011. In addition, the changes showed a significant difference between groups (p<.001). PubMedGoogle Scholar. + Helps to prevent signs of premature aging J Kor Soc Cosmetol. The wrinkles around the right eye for group C significantly increased by 1.17(M), from 14.52(M) to 15.70(M) (p<.05), group E1 showed a significant decrease of 1.82(M), from 13.84(M) to 12.01(M) (p<.05), and group E2 showed a statistically significant decrease of 2.45(M), from 16.39(M) to 13.93(M) (p<.001). They were instructed to wash their faces, smooth out their skin with a toner, and then apply the research samples on their faces. Something went wrong. The present study fabricated a polymer matrix that effectively stabilized ADSC-CM, which was an active ingredient, and applied a polymersome to E2. Most skincare products merely disguise or temporarily camouflage these skin concerns, but FRANZ'sStem Cell Culture Medium Ampoule is formulated to actively reverse the damage that is at the root of the symptoms which present as skin concerns. A study on clinical effectiveness of cosmetics containing human stem cell conditioned media, https://doi.org/10.1186/s41702-020-0056-9, https://www.ncbi.nlm.nih.gov/pubmed/14985162, https://www.ncbi.nlm.nih.gov/pubmed/?term=hibino+t+%26+nishiyama+t, https://pubs.acs.org/doi/10.1021/la703546f, http://www.koreascience.or.kr/article/JAKO200503042593001.page, http://www.koreascience.or.kr/article/JAKO200423606555446.page, http://e-ajbc.org/m/journal/view.php?number=1136, https://www.jdsjournal.com/article/S0923-1811, https://www.ncbi.nlm.nih.gov/pubmed/18379050, https://www.ncbi.nlm.nih.gov/pubmed/16616298, http://devkiss.kstudy.com/thesis/thesis-view.asp?key=3162015, https://www.ncbi.nlm.nih.gov/pubmed/15725748, http://www.jbc.org/content/272/7/3967.long, https://link.springer.com/chapter/10.1007/978-1-4615-3770-0_4, https://www.ncbi.nlm.nih.gov/pubmed/18528591, https://www.ncbi.nlm.nih.gov/pubmed/16880387, https://www.ncbi.nlm.nih.gov/pubmed/15105397, https://www.ncbi.nlm.nih.gov/pubmed/21605607, https://www.ncbi.nlm.nih.gov/pubmed/12475952, https://www.ncbi.nlm.nih.gov/pubmed/11304456, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. In the U-zone, group C showed a mean moisture decrease of 2.61(M), from 75.11(M) to 72.49(M) post-treatment (p<.05). Join our email list for exclusive offers and the latest news. Though we are thrilled to share our latest dermatological breakthrough with you, we also understand that stem cell skincare is still a very new technology and, therefore, may be linked to misinformation rather than facts.
2004;6(1):714 https://www.ncbi.nlm.nih.gov/pubmed/14985162 Accessed 2004. volume4, Articlenumber:9 (2020) In the Republic of Korea, much attention was paid to cosmetic raw materials using human stem cells as a new growth engine at the end of the 2000s. Accordingly, the Ministry of Food and Drug Safety implemented the Regulations on Cosmetic Safety Standards, etc., which contains the safety standards of human-derived cell and tissue culture as raw materials for cosmetics. 2005;35(6):4039 http://www.koreascience.or.kr/article/JAKO200503042593001.page Accessed 2005. ", - Echinacea Stem Cells address appearance of firmness, texture and tone - Pyrus Malus (Apple) Fruit Extract helps minimize the appearance of fine lines- Alpine Rose softens skin exposed to environmental stressors- Hyaluronic Acid provides continuous moisture, binding up to 1,000 times its weight in waterforming an ultra hydrating formula- Great for dull-looking skin and the visible signs of aging- Oil freeformula, Water (Aqua/Eau), Glycerin, Sodium Hyaluronate, Pyrus Malus Fruit Extract, Echinacea Angustifolia Meristem Cell Culture, Phyllostachys Edulis Shoot, Rhododendron Ferrugineum Flower Extract, Lysolecithin, Sclerotium Gum, Xanthan Gum, Pullulan, Gluconolactone, Sodium Benzoate, Calcium Gluconate, Citric Acid, Potassium Sorbate. Semin Cutan Med Surg. Krause K, Foitzik K. Biology of the hair follicle: the basics. J Dermatol Sci. Studies have proved that absorption through the skin is passive transport rather than active and that the stratum corneums unique role as a selective barrier is attributed to the complex structure of -keratin and lipids (Choi, 1999; Yang, 2003). Human Reprod. There were no significant differences between groups C, E1, and E2 for age and job (p>.05). However, human-adipose stem cells are derived from fat (not embryonic stem cells), making the process much easier, less painful, and has already been tested for decades via liposuction techniques. Therefore, we'd like to take this opportunity to address your concerns directly in this post focusing on stem-cell technology and skincare. 1997;272(7):396772 http://www.jbc.org/content/272/7/3967.long Accessed 1997. This study was performed through a joint research contract between Dasan C&Tech and Aphrozone in 2018 and was funded by Aphrozone. J Kor Soc Cosmetol. Elastin is one of the main components in the dermal extracellular matrix that provides skin tension and elasticity along with collagen so the elastin of ADSC-CM would contribute to skin elasticity recovery through percutaneous absorption (Mecham & Heuser, 1991).
YKH and AHJ performed the research background such as the experiments and data collection. In today's post, we'll start with the most frequently asked questions: Because stem cells have the potential to develop into many different types of cells they are the bodys natural repair system. statement and We all loved it, and then we asked a group of independent beauty panellists to test it. A Master's thesis of Konkuk University. 2003;3940, 4649, 5357. Google Scholar. Accessed 2010. Suitable for all skin types, including sensitive, A must-have in your skincare line-up to combat sun, A/C and winter. Absorb enough of it, and your face will look amazing. Accessed 2018. http://www.riss.kr/link?id=T14226972 Accessed 2016. - Use alone or layer under your favorite moisturizer for enhanced environmental protection. Han SM, Hong IP, Woo SO, Chun SN, Han CS. The main goal of the experiment was to have the subjects use accurate volumes of the research sample. Another study by Park reported that ADSCs were cultured to verify the presence of elastin in the cells and culture medium, and a higher elastin concentration was found in the culture supernatant than in the inside of the cells (Park, 2016). They were divided into a control group (C), an experimental group 1 (ADSC-CM 5% group, E1), and an experimental group 2 (polymersome-containing ADSC-CM 5% group, E2), and there were 20 subjects in each group. The skin permeation of substances is largely divided into two types: absorption through skin appendages (e.g., eccrine glands, apocrine glands, sebaceous glands, and hair follicles) and absorption through the epidermis. The skin safety and effects of the fermented broth of Lactobacillus rhamnosus for improving the neck skin. 2013;19(4):63441 http://devkiss.kstudy.com/thesis/thesis-view.asp?key=3162015. Furthermore, percutaneous absorption was improved compared with previous studies on formulations in relation to polymersome at the same concentration of ADSC-CM, thereby resulting in higher effectiveness. Effects on freeze-dried cosmetics made with spicule and stem cell culture media on the skin around eyes of middle-aged women. Terms and Conditions, Furthermore, the difference in higher effectiveness in wrinkles and elasticity than in melanin and erythema is interpreted as having greater effectiveness in the dermis at E2. J Dermatol Sci. All group (C, E1, and E2) subjects applied the research samples using an airbrush left it to be absorbed without using their hands. Martnez-Esparza M, Jimnez-Cervantes C, Beermann F, Aparicio P, Lozano JA, Garca-Borrn JC. Main wrinkles around the eyes were increased in C on both the right and left sides, whereas E1 showed a significant decrease (p<.05), and E2 showed a more significant decrease (p<.001) and it showed a significant difference between the groups (p<.001). In: Cell biology of extracellular matrix. J Soc Cosmet Scientists Korea. As a result, ADSC-CM proved to be effective for skin wrinkles and elasticity. You can also apply our Stem Cell Culture Medium Ampoule immediately to a sunburn to speed up the healing process. The study of the effect on middle-aged women's wrinkles around eyes by MTS and stem cell culture medium. Shim JH. - Apply to freshly cleansed skin, morning and evening. CAS Cookies policy. These results have verified that ADSC-CM is effective in skin whitening. In South Korea, much attention was paid to cosmetic raw materials using human stem cells as a new growth engine at the end of the 2000s. Among them, bone marrow stem cells have a limitation on clinical application due to low yield rate, whereas adipose tissue stem cells have relatively characterization of safe extraction, high yield of stem cells, with easy separation (Lin et al., 2005; Rodrguez et al., 2006; Tsai et al., 2004; Zuk et al., 2002, 2001). What both processes have in common are: they are voluntary, ethically conducted and are strictly regulated and vigorously tested to keep all involved parties healthy and happy. Kim WS, Park SH, Ahn SJ, Kim HK, Park JS, Lee GY, KIM KJ, WHANG KK, KANG SH, PARK BS, Sung JH. In addition, studies on the efficacy of human stem cell culture media with cosmetic materials have been steadily performed. The airbrush (M66, Dasan C&Tech, Korea) used for this study consisted of a spray gun, air compressor, air hose, and adapter. However, they were instructed to not make any changes in their daily living patterns, such as exercise, because changes in living patterns could affect their skin conditions. This study was approved by the Institutional Review Board of the Korea National Institute for Bioethics Policy following a comprehensive review of study-related procedures (Approval number: P0120180913-001). 2004;30(3):295305 http://www.koreascience.or.kr/article/JAKO200423606555446.page Accessed 2004. Opanasopit P, Ruktanonchai U, Suwantong O, Panomsuk S, Ngawhirunpat T, Sittisombut C, Suksamran T, Supaphol P. Electrospun poly (vinyl alcohol) fiber mats as carriers for extracts from the fruit hull of mangosteen. 41. 2019. http://www.riss.kr/link?id=T15109028 Accessed 2019. Through this, it expects to contribute greatly to the development and activation of cosmetic products containing ADSC-CM in the cosmetics industry. Correspondence to Google Scholar. The power of plant stem cells meets hardworking botanicals. In a study by Park, applying ADSC-CM when the microneedle therapy system (MTS) was conducted 2cm from the outside corners of the eyes of subjects and the experimental group significantly increased in the moisture content compared to the control group (p<.05) (Park, 2013). Yield of human adipose-derived adult stem cells from liposuction aspirates. of people agreed their skin looked smoother directly after use. Preparation and evaluation of polymer microspheres containing Broussonetia kazinoki root Extract. Subjects general characteristics are presented in Table4. Despite the same content of ADSC-CM in the E1 and E2, the difference in effectiveness can be logically attributed to the difference in formulations. 2018; 5457, 6871, 8184.
This formulation is a genuine scientific breakthrough that required decades of research and hard work to bring to market. 2011;63:124756 https://www.ncbi.nlm.nih.gov/pubmed/21605607 Accessed 2011. In addition, the changes showed a significant difference between groups (p<.001). PubMedGoogle Scholar. + Helps to prevent signs of premature aging J Kor Soc Cosmetol. The wrinkles around the right eye for group C significantly increased by 1.17(M), from 14.52(M) to 15.70(M) (p<.05), group E1 showed a significant decrease of 1.82(M), from 13.84(M) to 12.01(M) (p<.05), and group E2 showed a statistically significant decrease of 2.45(M), from 16.39(M) to 13.93(M) (p<.001). They were instructed to wash their faces, smooth out their skin with a toner, and then apply the research samples on their faces. Something went wrong. The present study fabricated a polymer matrix that effectively stabilized ADSC-CM, which was an active ingredient, and applied a polymersome to E2. Most skincare products merely disguise or temporarily camouflage these skin concerns, but FRANZ'sStem Cell Culture Medium Ampoule is formulated to actively reverse the damage that is at the root of the symptoms which present as skin concerns. A study on clinical effectiveness of cosmetics containing human stem cell conditioned media, https://doi.org/10.1186/s41702-020-0056-9, https://www.ncbi.nlm.nih.gov/pubmed/14985162, https://www.ncbi.nlm.nih.gov/pubmed/?term=hibino+t+%26+nishiyama+t, https://pubs.acs.org/doi/10.1021/la703546f, http://www.koreascience.or.kr/article/JAKO200503042593001.page, http://www.koreascience.or.kr/article/JAKO200423606555446.page, http://e-ajbc.org/m/journal/view.php?number=1136, https://www.jdsjournal.com/article/S0923-1811, https://www.ncbi.nlm.nih.gov/pubmed/18379050, https://www.ncbi.nlm.nih.gov/pubmed/16616298, http://devkiss.kstudy.com/thesis/thesis-view.asp?key=3162015, https://www.ncbi.nlm.nih.gov/pubmed/15725748, http://www.jbc.org/content/272/7/3967.long, https://link.springer.com/chapter/10.1007/978-1-4615-3770-0_4, https://www.ncbi.nlm.nih.gov/pubmed/18528591, https://www.ncbi.nlm.nih.gov/pubmed/16880387, https://www.ncbi.nlm.nih.gov/pubmed/15105397, https://www.ncbi.nlm.nih.gov/pubmed/21605607, https://www.ncbi.nlm.nih.gov/pubmed/12475952, https://www.ncbi.nlm.nih.gov/pubmed/11304456, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. In the U-zone, group C showed a mean moisture decrease of 2.61(M), from 75.11(M) to 72.49(M) post-treatment (p<.05). Join our email list for exclusive offers and the latest news. Though we are thrilled to share our latest dermatological breakthrough with you, we also understand that stem cell skincare is still a very new technology and, therefore, may be linked to misinformation rather than facts. 2004;6(1):714 https://www.ncbi.nlm.nih.gov/pubmed/14985162 Accessed 2004. volume4, Articlenumber:9 (2020) In the Republic of Korea, much attention was paid to cosmetic raw materials using human stem cells as a new growth engine at the end of the 2000s. Accordingly, the Ministry of Food and Drug Safety implemented the Regulations on Cosmetic Safety Standards, etc., which contains the safety standards of human-derived cell and tissue culture as raw materials for cosmetics. 2005;35(6):4039 http://www.koreascience.or.kr/article/JAKO200503042593001.page Accessed 2005. ", - Echinacea Stem Cells address appearance of firmness, texture and tone - Pyrus Malus (Apple) Fruit Extract helps minimize the appearance of fine lines- Alpine Rose softens skin exposed to environmental stressors- Hyaluronic Acid provides continuous moisture, binding up to 1,000 times its weight in waterforming an ultra hydrating formula- Great for dull-looking skin and the visible signs of aging- Oil freeformula, Water (Aqua/Eau), Glycerin, Sodium Hyaluronate, Pyrus Malus Fruit Extract, Echinacea Angustifolia Meristem Cell Culture, Phyllostachys Edulis Shoot, Rhododendron Ferrugineum Flower Extract, Lysolecithin, Sclerotium Gum, Xanthan Gum, Pullulan, Gluconolactone, Sodium Benzoate, Calcium Gluconate, Citric Acid, Potassium Sorbate. Semin Cutan Med Surg. Krause K, Foitzik K. Biology of the hair follicle: the basics. J Dermatol Sci. Studies have proved that absorption through the skin is passive transport rather than active and that the stratum corneums unique role as a selective barrier is attributed to the complex structure of -keratin and lipids (Choi, 1999; Yang, 2003). Human Reprod. There were no significant differences between groups C, E1, and E2 for age and job (p>.05). However, human-adipose stem cells are derived from fat (not embryonic stem cells), making the process much easier, less painful, and has already been tested for decades via liposuction techniques. Therefore, we'd like to take this opportunity to address your concerns directly in this post focusing on stem-cell technology and skincare. 1997;272(7):396772 http://www.jbc.org/content/272/7/3967.long Accessed 1997. This study was performed through a joint research contract between Dasan C&Tech and Aphrozone in 2018 and was funded by Aphrozone. J Kor Soc Cosmetol. Elastin is one of the main components in the dermal extracellular matrix that provides skin tension and elasticity along with collagen so the elastin of ADSC-CM would contribute to skin elasticity recovery through percutaneous absorption (Mecham & Heuser, 1991).
YKH and AHJ performed the research background such as the experiments and data collection. In today's post, we'll start with the most frequently asked questions: Because stem cells have the potential to develop into many different types of cells they are the bodys natural repair system. statement and We all loved it, and then we asked a group of independent beauty panellists to test it. A Master's thesis of Konkuk University. 2003;3940, 4649, 5357. Google Scholar. Accessed 2010. Suitable for all skin types, including sensitive, A must-have in your skincare line-up to combat sun, A/C and winter. Absorb enough of it, and your face will look amazing. Accessed 2018. http://www.riss.kr/link?id=T14226972 Accessed 2016. - Use alone or layer under your favorite moisturizer for enhanced environmental protection. Han SM, Hong IP, Woo SO, Chun SN, Han CS. The main goal of the experiment was to have the subjects use accurate volumes of the research sample. Another study by Park reported that ADSCs were cultured to verify the presence of elastin in the cells and culture medium, and a higher elastin concentration was found in the culture supernatant than in the inside of the cells (Park, 2016). They were divided into a control group (C), an experimental group 1 (ADSC-CM 5% group, E1), and an experimental group 2 (polymersome-containing ADSC-CM 5% group, E2), and there were 20 subjects in each group. The skin permeation of substances is largely divided into two types: absorption through skin appendages (e.g., eccrine glands, apocrine glands, sebaceous glands, and hair follicles) and absorption through the epidermis. The skin safety and effects of the fermented broth of Lactobacillus rhamnosus for improving the neck skin. 2013;19(4):63441 http://devkiss.kstudy.com/thesis/thesis-view.asp?key=3162015. Furthermore, percutaneous absorption was improved compared with previous studies on formulations in relation to polymersome at the same concentration of ADSC-CM, thereby resulting in higher effectiveness. Effects on freeze-dried cosmetics made with spicule and stem cell culture media on the skin around eyes of middle-aged women. Terms and Conditions, Furthermore, the difference in higher effectiveness in wrinkles and elasticity than in melanin and erythema is interpreted as having greater effectiveness in the dermis at E2. J Dermatol Sci. All group (C, E1, and E2) subjects applied the research samples using an airbrush left it to be absorbed without using their hands. Martnez-Esparza M, Jimnez-Cervantes C, Beermann F, Aparicio P, Lozano JA, Garca-Borrn JC. Main wrinkles around the eyes were increased in C on both the right and left sides, whereas E1 showed a significant decrease (p<.05), and E2 showed a more significant decrease (p<.001) and it showed a significant difference between the groups (p<.001). In: Cell biology of extracellular matrix. J Soc Cosmet Scientists Korea. As a result, ADSC-CM proved to be effective for skin wrinkles and elasticity. You can also apply our Stem Cell Culture Medium Ampoule immediately to a sunburn to speed up the healing process. The study of the effect on middle-aged women's wrinkles around eyes by MTS and stem cell culture medium. Shim JH. - Apply to freshly cleansed skin, morning and evening. CAS Cookies policy. These results have verified that ADSC-CM is effective in skin whitening. In South Korea, much attention was paid to cosmetic raw materials using human stem cells as a new growth engine at the end of the 2000s. Among them, bone marrow stem cells have a limitation on clinical application due to low yield rate, whereas adipose tissue stem cells have relatively characterization of safe extraction, high yield of stem cells, with easy separation (Lin et al., 2005; Rodrguez et al., 2006; Tsai et al., 2004; Zuk et al., 2002, 2001). What both processes have in common are: they are voluntary, ethically conducted and are strictly regulated and vigorously tested to keep all involved parties healthy and happy. Kim WS, Park SH, Ahn SJ, Kim HK, Park JS, Lee GY, KIM KJ, WHANG KK, KANG SH, PARK BS, Sung JH. In addition, studies on the efficacy of human stem cell culture media with cosmetic materials have been steadily performed. The airbrush (M66, Dasan C&Tech, Korea) used for this study consisted of a spray gun, air compressor, air hose, and adapter. However, they were instructed to not make any changes in their daily living patterns, such as exercise, because changes in living patterns could affect their skin conditions. This study was approved by the Institutional Review Board of the Korea National Institute for Bioethics Policy following a comprehensive review of study-related procedures (Approval number: P0120180913-001). 2004;30(3):295305 http://www.koreascience.or.kr/article/JAKO200423606555446.page Accessed 2004. Opanasopit P, Ruktanonchai U, Suwantong O, Panomsuk S, Ngawhirunpat T, Sittisombut C, Suksamran T, Supaphol P. Electrospun poly (vinyl alcohol) fiber mats as carriers for extracts from the fruit hull of mangosteen. 41. 2019. http://www.riss.kr/link?id=T15109028 Accessed 2019. Through this, it expects to contribute greatly to the development and activation of cosmetic products containing ADSC-CM in the cosmetics industry. Correspondence to Google Scholar. The power of plant stem cells meets hardworking botanicals. In a study by Park, applying ADSC-CM when the microneedle therapy system (MTS) was conducted 2cm from the outside corners of the eyes of subjects and the experimental group significantly increased in the moisture content compared to the control group (p<.05) (Park, 2013). Yield of human adipose-derived adult stem cells from liposuction aspirates. of people agreed their skin looked smoother directly after use. Preparation and evaluation of polymer microspheres containing Broussonetia kazinoki root Extract. Subjects general characteristics are presented in Table4. Despite the same content of ADSC-CM in the E1 and E2, the difference in effectiveness can be logically attributed to the difference in formulations. 2018; 5457, 6871, 8184.